Department of Biomedical Engineering
University of California, Davis
12 PM, Tuesday, May 9th, 2017
1065 Kemper Hall
Abstract: This presentation overviews fluorescence lifetime spectroscopy and imaging techniques for label-free in vivo characterization of biological tissues. Emphasis is placed on recently developed devices and methods enabling real-time characterization and diagnosis of diseased tissues during clinical interventions. I will present studies conducted in animal models and human patients demonstrating the ability of lifetime fluorescence techniques to provide rapid in-situ evaluation of tissue biochemistry and their potential to guide surgical, biopsy, and intravascular procedures. Current results demonstrate that tissue intrinsic fluorescence features can provide useful contrast for diagnosis of vulnerable atherosclerotic plaques and for intraoperative delineation of brain tumors and head and neck tumors. Finally, I will present results from the first-in-human study focused on the integration of a scanning multispectral fluorescence lifetime technique with the da Vinci surgical robot and demonstrating the potential of this technique as a tool for augmented reality during trans-oral robotic surgery (TORS).
Biography: Laura Marcu is a Professor of Biomedical Engineering and Neurological Surgery at University of California at Davis. She received her doctorate degree in biomedical engineering from the University of Southern California in 1998. Prior of joining UC Davis in 2006 she served as the Director of the Biophotonics Research Laboratory at Cedars-Sinai Medical Center and was a Research Associate Professor of Electrical Engineering-Electrophysics and Biomedical Engineering at the University of Southern California. Her research interests include the development of fluorescence-based instrumentation and multimodal imaging systems which enable studies of the molecular, metabolic and morphologic changes in living systems ranging from biological cells and animal models to human patients. She is co-editor of the first textbook on Fluorescence Lifetime Spectroscopy and Imaging: Principles and Applications in Biomedical Diagnostics. Currently she serves as associate editor of the Biomedical Optics Express and is an editorial board member for the Journal of Biophotonics. Dr. Marcu is a fellow of the Optical Society of America (OSA), the International Society of Optical Engineers (SPIE), the Biomedical Engineering Society (BMES), and the American Institute of Biomedical Engineering (AIMBE).